PO-244 Inhibitory effects of isoliquiritigenin on TGF-β-induced epithelial-to-mesenchymal transition of human endometrial cancer cells
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Inhibitory effects of dieckol on hypoxia-induced epithelial-mesenchymal transition of HT29 human colorectal cancer cells
Hypoxia-induced epithelial-mesenchymal transition (EMT) has been identified as essential for tumor progression and metastasis. The present study examined the effects of an antioxidant, dieckol, on hypoxia‑induced EMT in HT29 human colorectal cancer cells. HT29 cells were treated with a hypoxia‑inducing agent, CoCl2, and an increase in the levels of intracellular reactive oxygen species (ROS) an...
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BACKGROUND Chronic airway inflammatory disorders, such as asthma, are characterized by airway inflammation and remodeling. Chronic inflammation and damage to the airway epithelium cause airway remodeling, which is associated with improper epithelial repair, and is characterized by elevated expression of transforming growth factor-β (TGF-β). Epithelial-mesenchymal transition (EMT) is an importan...
متن کاملNox4-derived ROS signaling contributes to TGF-β-induced epithelial-mesenchymal transition in pancreatic cancer cells.
UNLABELLED Transforming growth factor (TGF)-β induces epithelial-mesenchymal transition (EMT) in pancreatic adenocarcinoma. In this study, we investigated how NADPH oxidase (Nox) 4-generated reactive oxygen species (ROS) regulate TGF-β-induced EMT in pancreatic cancer cells. MATERIALS AND METHODS Pancreatic cancer cells were transfected with Nox4 siRNAs or PTP1B mutants and subjected to TGF-β...
متن کاملMesenchymal Stem Cells Trigger Epithelial to Mesenchymal Transition in the HT-29 Colorectal Cancer Cell Line
Background and Objective: Mesenchymal stem cells (MSCs) promote metastasis in colorectal cancer; however, the mechanism underlying this process is not fully understood. Epithelial to mesenchymal transition (EMT) is a key step in tumor acquisition of metastatic phenotype. We aimed to investigate the effect of MSCs on the expression of EMT markers, as well as cancer stem cell markers in HT-29 col...
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Epithelial-to-mesenchymal transition (EMT) is the cancer-associated process wherein an epithelial cell converts into a mesenchymal type cell. Mesenchymal cells lack apical polarity and secrete extracellular-matrix-degrading enzymes that provide them with enhanced migration capabilities. Moreover, EMT is closely related to cancer stem cell-like phenotype mutations, such as chemotherapy resistanc...
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ژورنال
عنوان ژورنال: ESMO Open
سال: 2018
ISSN: 2059-7029
DOI: 10.1136/esmoopen-2018-eacr25.760